F8 and renal colic: In the case of mild muscle or joint bleeding or gross hematuria, the use of 30 IU/kg of FVIII concentrate is recommended, with a reevaluation at 12/24 hours.17To avoid a renal colic related to blood clots in the ureters in patients with gross hematuria, before the administration of FVIII concentrate it is recommended to give intravenous fluids until the color of the urine changes to a pinker shade.2, 22