In breast cancer MCF-7 and NSCLC cells, AA downregulated Bcl-2 and upregulated Bax, resulting in the release of Cyt-c from mitochondria and increasing the expression of cleaved PARP, which ultimately led to apoptosis (Liu et al., 2019; Haffez et al., 2022). This evidence concerns the gene BCL2 and non-small cell lung carcinoma.