PIK3CA and Insulin resistance: The analysis revealed enrichment of genes interacting with CDK4/6is in various pathways, notably, central carbon metabolism in cancer, the FoxO signaling pathway, insulin resistance, the HIF-1 signaling pathway, cellular senescence, microRNAs in cancer, PD-L1 expression and the PD-1 checkpoint pathway in cancer, the Toll-like receptor signaling pathway, apoptosis, small cell lung cancer, and the PI3K-Akt signaling pathway.