NR3C1 and psychiatric disorder: Methylation of the NR3C1 gene in its promoter region is connected to diminished expression of the glucocorticoid receptor (GR) and to disruption of the hypothalamic–pituitary–adrenal (HPA) axis, and is implicated in the development of psychiatric disorders among individuals exposed to psychosocial stress, early trauma, post-traumatic stress, gestational hunger, neglect, and various other adverse conditions (55, 77, 78).