The hypothalamus is thought to modulatethese brain structures.48 Long-term stimulationof the trigeminovascular system and hyperexcitabilityof trigeminal neurons cause the nociceptive pain threshold to decreaseand the pain to turn into chronic headache.43 Pituitary adenylate cyclase-activating polypeptide (PACAP) and pituitaryadenylate cyclase-activating polypeptide type 1 (PAC1) receptors arepotential targets that are expressed in the trigeminovascularsystem and may cause migraine attacks. Here, ADCYAP1 is linked to headache disorder.