HMGB1 and disease of the tendon: Intriguingly, recent studies have also shown that HMGB1, as a damage-associated molecular pattern (DAMP) or an alarmin, is increased and plays significant roles in human [18, 21], mouse [22, 23], and rat [24, 25] tendinopathy, such as proinflammatory response and matrix regulation, suggesting that HMGB1 may be a potential new target for tendinopathy treatment [26].