The NPPA gene located on chromosome 1p36.22 encodes for the atrial natriuretic polypeptide (ANP) precursor [95, 96] and a common variant, NPPA rs5065 (T2238C, c.454T>C, p.Ter152Arg) has been reported to be associated with antihypertensive medication effects on cardiovascular disease and BP [97], results which emanated from a huge study assessing about 38,000 patients, of which 35% were Africans on different antihypertensive medication. Here, NPPA is linked to cardiovascular disorder.