Yet, in specific clinical scenarios that can impair it, like Congenital Nephrotic Syndrome (CNS) or Short Bowel Syndrome (SBS) due to absorption issues, anti-thrombin III (AT-III) deficiency and non-selective proteinuria, adjusting the dosage to achieve appropriate plasma concentrations could prove beneficial. The gene discussed is SERPINC1; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.