However, when we analysed animals at 12/14 months of age, the severity of histological lesions increased to the same extent in all animals, despite double KO animals exhibiting less polyuria and LMW proteinuria and displaying lower mRNA expression of Il6 and Mcp1. Altogether, these results demonstrate a role for Nlrp2 in the progression of kidney disease in the Ctns-/- mouse model, and show that inhibition of this NOD-like receptor family member can partially delay disease onset. Here, CCL2 is linked to kidney disorder.