Despite the fact that we previously reported an increase in IL-10 secretion from CD4+ Foxp3+ Treg in septic anti-CD28-treated immunologically experienced mice (10), no difference in 7-day survival was observed when Tregs were depleted in the setting of CD28 agonism during sepsis (50% vs. 50%, p=0.617, Figure 1B), indicating that Tregs did not modify sepsis survival under these conditions. The gene discussed is CD28; the disease is Sepsis.