The gene ANAPC4 was found significantly in the eQTL of lung tissue in both critical COVID-19 (PSMR=1.67E-02) and chronic pain (PSMR=1.07E-04), the most significant Psmr of COVID-19 is in brain nucleus accumbens basal ganglia (PCOVID-19 = 0.031,PHEIDI=0.47) and the corresponding Psmr of chronic pain is 1.46E-05. This evidence concerns the gene ANAPC4 and COVID-19.