PPARA and metabolic dysfunction-associated steatohepatitis: In this study, WT mice and PPARα knockout (PPARαko) mice gavaged with folium sennae (SE) were used as the SD model, a methionine–choline-deficient (MCD) diet was used as an incentive for NASH, and the molecular biology techniques and transcriptomics were utilized for detecting changes in inflammation, lipid metabolism, and PPARα expression.