In line with the KEGG analysis, gene set enrichment analysis (GSEA) showed that the DEGs (NAFLD-SD vs. NAFLD) were negatively correlated with the “PPAR signaling pathway” categories and were positively correlated with inflammation, suggesting that these changes could regulate the nuclear receptor and inflammation (Figures 1E, F). The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatotic liver disease.