In fact, abnormal expression of TIMD4 has been reported in diverse cancer cells including diffuse large B‐cell lymphoma (DLBCL), non‐small‐cell lung cancer, glioma, renal cell carcinoma and histiocytic sarcoma and usually associated with adverse prognosis [48, 49, 50, 51, 52, 53]. This evidence concerns the gene TIMD4 and renal cell carcinoma.