CT26 colorectal cancer cell-derived exosomes can carry and deliver specific tumor antigens (such as HSP70, Mart1, Her2/Neu, gp100, and TRP), reduce the number of Tregs, increase the number of CD8+ T cells, upregulate the level of IFN-γ, and trigger the immune response in vivo (Ganji et al., 2020). This evidence concerns the gene CD8A and colorectal cancer.