The exosomes derived from CAFs in TME overexpress microRNA-92, downregulate the target gene LATS2, enhance the nuclear translocation of YAP1 in the PD-L1 enhancer region, increase the transcriptional activity of PD-L1, and inhibit the function of immune cells in breast cancer through the miR-92/PD-L1 pathway (Dou et al., 2020). The gene discussed is CD274; the disease is breast cancer.