For example, adoptive immune cell CAR-T cells and exosomes can reduce the expression of Ki-67, Gzms-B, IFN-γ and TNF-α, and improve CD8+ T cell invasion and activation (Zhong et al., 2023b), and exosomes containing CAR express high levels of cytotoxic molecules that significantly inhibit tumor growth (Fu et al., 2019). The gene discussed is TNF; the disease is neoplasm.