CD8A and neoplasm: For example, adoptive immune cell CAR-T cells and exosomes can reduce the expression of Ki-67, Gzms-B, IFN-γ and TNF-α, and improve CD8+ T cell invasion and activation (Zhong et al., 2023b), and exosomes containing CAR express high levels of cytotoxic molecules that significantly inhibit tumor growth (Fu et al., 2019).