For example, in the study of melanoma cells, it has been found that administration of exosomes derived from activated CD8+ T cells can exhaust fibro blastoma stromal cells composed of MSCs and cancer-associated fibroblasts (CAFs), disrupt tumor progression, and result in loss of invasiveness and metastasis of melanoma cells (Seo et al., 2018). Here, CD8A is linked to neoplasm.