In breast cancer, exosomes containing miR-33 by targeting macrophage polarization regulatory factor MafB, downregulate M2 markers such as CD206, Arg-1, TGF-β, IL-10, and upregulate M1 markers such as CD86, NOS2, TNF-α, and IL-1β, and induced M2 to transform into M1 macrophages to inhibit tumor cell migration and invasion (Moradi-Chaleshtori et al., 2021). Here, TNF is linked to neoplasm.