Breast cancer cell-derived exosomes transmit the lncRNA SNHG16 to induce CD73+γδ1 Treg cells (Ni et al., 2020), miR-27a-3p on exosomes induced by endoplasmic reticulum stress can regulate PD-L1 expression in macrophages to promote immune escape of breast cancer (Yao et al., 2020), and Lin28B-hyper-expressed exosomes can promote immunosuppression and cancer progression in the premetastatic niche in the lung (Qi et al., 2022). This evidence concerns the gene CD274 and breast cancer.