Genes that were downregulated in APS-1 patients included chemokine ligands (CCL) 3, CCL4 and CCL5, chemokine receptors CXCR3 and CXCR6, in addition to granzyme (GZM) B and TNFSF10 (Figures 2F and 2G). This evidence concerns the gene CCL4 and autoimmune polyendocrine syndrome type 1.