To test whether whole‐body IL‐6 knockout (IL‐6−/−) mice would be refractory to cachexia development and ketogenic impairment, we implanted wild‐type (WT) and IL‐6−/− mice with PDAC tumours and maintained them on an ad libitum diet for 11 days, at which timepoint WT mice have fully developed cachexia. This evidence concerns the gene IL6 and neoplasm.