IL6 and Cachexia: To test whether whole‐body IL‐6 knockout (IL‐6−/−) mice would be refractory to cachexia development and ketogenic impairment, we implanted wild‐type (WT) and IL‐6−/− mice with PDAC tumours and maintained them on an ad libitum diet for 11 days, at which timepoint WT mice have fully developed cachexia.