In module 3, the results indicated that RUNX1 [25, 26], ZBTB16 [27], GATA2 [28, 29] and MEIS1 [30] which involved in the myeloid cell differentiation and the pathogenesis of acute leukemia showed higher levels of expression in cells from the MDS across differentiation (Fig. 2F). This evidence concerns the gene RUNX1 and acute leukemia.