ZBTB16 and acute leukemia: In module 3, the results indicated that RUNX1 [25, 26], ZBTB16 [27], GATA2 [28, 29] and MEIS1 [30] which involved in the myeloid cell differentiation and the pathogenesis of acute leukemia showed higher levels of expression in cells from the MDS across differentiation (Fig. 2F).