In terms of protein expression, the expression of PLCB1 in bone marrow biopsy specimens of MDS patients was detected by immunohistochemical method, and it was found that the expression of PLCB1 in patients with MDS-EB was significantly higher than that in HCs and those without EB (p = 0.003, p = 0.001, respectively) (Fig. 4I). The gene discussed is PLCB1; the disease is myelodysplastic syndrome.