Of note, the Nrf2/Keap1 signal pathway is characterized with multifaceted functions which participates in the regulation of multiple diseases, especially in cancer, and previous publications suggest that Nrf2/Keap1 plays critical role in regulating the initiation, progression and aggravation of prostate cancer [32], ovarian cancer [33] and cervical endometrial cancers [34]. Here, KEAP1 is linked to Familial prostate cancer.