On the other hand, IL-6, secreted by M2 macrophages, enhances the phosphorylation of phosphoglycerate kinase 1 (PGK1) threonine 243 mediated by 3-phosphatidylinositol-dependent protein kinase 1 (PDPK1) in tumor cells, thereby regulating the direction of PGK1-catalyzed reactions and promoting tumor cell glycolysis and tumorigenesis [64]. Here, PDPK1 is linked to neoplasm.