Chemokines such as CCL5 and CCL18 produced by GAMs could upregulate the key enzymes of tumor cell glycolytic pathway, such as lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PD), further promoting tumor cell glycolysis and exacerbating the accumulation of lactate in the microenvironment, forming a vicious cycle [62]. This evidence concerns the gene CCL18 and neoplasm.