GPD2 and central nervous system cancer: Furthermore, IL-1β, produced by M2 macrophages, activates the phosphorylation of glycerol-3-phosphate dehydrogenase (GPD2) on threonine 10 (GPD2 pT10) in glioma cells, which enhances the affinity of GPD2 pT10 to substrate, and improves the catalytic rate of glycolysis in glioma cells [63].