Therefore, targeting the disordered cholesterol metabolism in GBM, Wang et al. developed an oncolytic adenovirus loaded with the cholesterol reverse transporter apolipoprotein A1 (ApoA1), for the treatment of GBM, which restores macrophages phagocytosis by manipulating cholesterol efflux and reactivates anti-tumor immunity [89]. Here, APOA1 is linked to glioblastoma.