SLC9A1 and central nervous system cancer: Hasan et al. discovered in murine glioma models that temozolomide combined with HOE642, a specific inhibitor of NHE1, significantly promoted infiltration of GAMs and T cells, facilitated Th1 activation, and upregulated mitochondrial oxidative phosphorylation pathway genes in GAMs, enhanced glucose uptake and mitochondrial activity in immune cells, and diminished aerobic glycolysis in GAMs [60].