Moreover, because the onset of ALS seems to involve a multistep process with a long preclinical stage and widespread BCSFB dysfunction that can be detected even in the presymptomatic-stage of ALS, we suggest that, similar to other neurodegenerative diseases, CP enlargement may also emerge in earlier stages in ALS patients [2–5, 23, 24]. This evidence concerns the gene CP and neurodegenerative disease.