CCN4 and obesity due to melanocortin 4 receptor deficiency: In addition, inflammation-rich proteins were identified in this analysis, and their association with PCOS has been reported in the literature,such as A1BG,APOC1,AZGP1,CCN4 and etc. [31–34], have a tight connection to the metabolism of lipids, glucose, and obesity, inflammatory response, and insulin resistance,indicating their diagnostic value in PCOS.