Liu Y et al. proposed that ZAG may inhibit ERK phosphorylation mediated by TGF-β and inhibit neuroinflammation mediated by TNF-α and IL-6 [35].β-α2-Glycoprotein (ZAG) has been shown to be associated with IR and PCOS [32], respectively. This evidence concerns the gene IL6 and polycystic ovary syndrome.