Interestingly, all three genes have increased expression in microglia [64, 65] and are part of a gene signature in a mouse model of amyotrophic lateral sclerosis, where expression of IFIT3 and TYROBP increased during disease progression in the mice microglia, macrophages, neutrophils, and monocytes [66]. Here, TYROBP is linked to amyotrophic lateral sclerosis.