Genetic variations and differential expression of NDUFV1 are associated with several human neurological disorders, including Mitochondrial Complex I Deficiency, Parkinson disease (PD), Alzheimer’s Disease (AD), myoclonic epilepsy, schizophrenia, Leigh syndrome and leukoencephalopathy [35–45]. The gene discussed is NDUFV1; the disease is early-onset autosomal dominant Alzheimer disease.