Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease [67], PRKCA is associated with neural basis of episodic remembering in healthy individuals [68] and KCNMB4 is downregulated in hippocampal granule neurons following seizure activity [69]. Here, KCNMB4 is linked to early-onset autosomal dominant Alzheimer disease.