GPAM and Cirrhosis: Notably, rare pLoF variants in GPAM were associated with lower ALT levels (−0.29 s.d. units per allele, 95% CI: −0.40 to −0.16, P = 5.8 × 10−6) and numerically lower odds of cirrhosis, although the latter association did not reach statistical significance (OR: 0.36, 95% CI: 0.05–2.42, P = 0.296; Supplementary Table 23).