GPAM and Cirrhosis: In contrast, the missense variant p.Ile42Val (rs2792751) in GPAM had a positive effect on both ALT levels (0.006 s.d. units per allele, 95% CI: 0.005–0.007, P = 7.0 × 10−45) and cirrhosis (OR: 1.09, 95% CI: 1.06–1.12, P = 6.4 × 10−11).