We found that rs738408 in PNPLA3 interacted significantly with T2D (P = 7.9 × 10−6), BMI (P = 3.0 × 10−6) and weekly alcohol intake (P = 1.2 × 10−5) on the risk of cirrhosis (Supplementary Table 14). The gene discussed is PNPLA3; the disease is type 2 diabetes mellitus.