We found proportional effects between NAFLD and ALD, except for three variants (p.His48Arg in ADH1B, PHet = 4.4 × 10−14; rs28636836 in HSD17B13, PHet = 1.8 × 10−4; and rs28712821 in KLB, PHet = 7.9 × 10−4), which had significantly larger effects on ALD than on NAFLD (PHet < 0.05/36). Here, ADH1B is linked to metabolic dysfunction-associated steatotic liver disease.