GPT and Cirrhosis: We selected 18 genes based on gene-prioritization analyses that had at least two lines of evidence and then evaluated rare variants (allele frequency <0.1%) that were predicted to cause loss-of-function (pLoF) and/or missense variants (with a Combined Annotation Dependent Depletion (CADD) score of at least 20) for their association with ALT and cirrhosis.