GPT and Cirrhosis: Similar to the missense variant p.Glu167Lys (rs58542926), rare coding variants in TM6SF2 were also associated with higher ALT levels (0.10 s.d. units per allele, 95% CI: 0.07–0.13, P = 2.0 × 10−10) and increased risk of cirrhosis (OR: 2.07, 95% CI: 1.43–3.00, P = 1.0 × 10−4).