PNPLA3 and Cirrhosis: We observed that rare coding variants (pLoF + missense) and pLoF variants (excluding missense) in PNPLA3 were both nominally associated with increased cirrhosis risk (pLoF + missense—OR: 1.86; 95% CI: 1.19–2.90; P = 6.0 × 10−3; pLoF—OR: 2.97; 95% CI: 1.09–8.15; P = 0.034; Supplementary Table 23).