IL1B and myelodysplastic syndrome: Initial gene expression profiling of 730 immune-related genes in SF3B1mut versus SF3B1wt MDS BM mononuclear cells (BM-MNCs) revealed a predominantly myeloid cell-related innate immune gene signature (e.g., CYBB, CSF1R) lacking signs of overt myeloid-driven inflammation (i.e. IL1B, CXCL5), whereas lymphoid-related genes were underrepresented (e.g., CD3D, CD79A) (Supplementary Table S4, Fig. S2).