However, HLA-DRlow/neg CM from one SF3B1K700E LR-MDS patient with co-mutations in TET2 and DNMT3A had a less stimulatory effect on the proliferative capability of autologous CD4+ T cells compared to their HLA-DRhigh counterparts (Supplementary Fig. S10). This evidence concerns the gene CD4 and myelodysplastic syndrome.