INS and type 2 diabetes mellitus: They claimed that exosomes released from human umbilical cord mesenchymal stem cells (hUCMSCs-Exos) could not only indirectly reverse insulin resistance to enhance glucose metabolism, increase glycogen storage in liver, but also suppress β-cells apoptosis induced by STZ, consequently restoring the insulin-secreting function and sustaining glucose homeostasis in rat with T2DM.