Diabetic erectile dysfunction (DED) involves multiple pathogenesis, such as the dysregulation of VEGF signaling transduction due to hyperglycemia, elevated levels of advanced glycation end products (AGEs), the synthesis of nitric oxide synthase (NOS), heightened production of oxygen free radicals in neurons, and reduced NO and cyclic guanosine monophosphate (cGMP)-dependent protein kinase-1 (cGKI) [160]. The gene discussed is VEGFA; the disease is Hyperglycemia.