Moreover, METTL3 increased the expression of circIGF2BP3 through m6A modification, and further enhanced the expression of PD-L1 through the miR-328-3p/miR-3173-5p/PKP3/OTUB1 pathway, ultimately leading to immune escape in non-small cell lung cancer [138]. Here, PKP3 is linked to non-small cell lung carcinoma.