However, let-7a-5p, let-7c-5p, and let-7f.-5p were interacted with the same 14 CRC genes, including AKT2, APC2, BCL2, BRAF, CASP3, MAPK10, MAPK8, MSH2, MSH6, PIK3CA, PIK3R5, SMAD2, TGFBR1, and TP53. Here, AKT2 is linked to colorectal carcinoma.