However, let-7a-5p, let-7c-5p, and let-7f.-5p were interacted with the same 14 CRC genes, including AKT2, APC2, BCL2, BRAF, CASP3, MAPK10, MAPK8, MSH2, MSH6, PIK3CA, PIK3R5, SMAD2, TGFBR1, and TP53. Here, MSH6 is linked to colorectal carcinoma.