However, let-7a-5p, let-7c-5p, and let-7f.-5p were interacted with the same 14 CRC genes, including AKT2, APC2, BCL2, BRAF, CASP3, MAPK10, MAPK8, MSH2, MSH6, PIK3CA, PIK3R5, SMAD2, TGFBR1, and TP53. The gene discussed is SMAD2; the disease is colorectal carcinoma.