TGFB1 and cancer: The results also suggest that the highly expressed exosomal miRNAs, e.g., let-7a-5p, let-7c-5p, let-7f.-5p, miR-423-5p and miR-3184-5p, are connected to cancer and are potentially important in CRC by targeting TGFβ, which is the important signaling in the CRC pathway (Fig. 8).