The results also suggest that the highly expressed exosomal miRNAs, e.g., let-7a-5p, let-7c-5p, let-7f.-5p, miR-423-5p and miR-3184-5p, are connected to cancer and are potentially important in CRC by targeting TGFβ, which is the important signaling in the CRC pathway (Fig. 8). Here, TGFB1 is linked to colorectal carcinoma.