It was identified that expression of TGF-β is affected by specific miR-99 family members such as miR-99a-5p, but not miR-99b-5p, and target SMAD2 and SMAD4 genes in acute megakaryoblastic leukemia (AMKL)67,74. The gene discussed is SMAD4; the disease is acute megakaryoblastic leukemia.