Moreover, since c-Fos, a downstream transcription factor governed by the expression of ELK3 [13], is critical in forming the AP-1 complex, which is known to involve ~50–60% of gene expression in eukaryotic cells, we believe that ELK3 protein content control may provide a critical clue for finding a new strategy to resolve PCa malignance. This evidence concerns the gene FOS and posterior cortical atrophy.