Although HS-276 has been shown to attenuate clinical symptoms in a mouse model for Rheumatoid arthritis, an inflammatory disease driven by TNFα mediated NF-κB stimulation via TAK1 [32], we have so far not been able to observe a survival benefit of treating mice transplanted orthotopically with mesenchymal gliomas with HS-276. This evidence concerns the gene MAP3K7 and rheumatoid arthritis.