Interferons play an important immunomodulatory role in several cancer types as they can promote tumor cell immune-evasion via downregulation of tumor-associated antigen presentation [40], upregulation of cytotoxic T cell inhibitor PD-L1 [41, 42], and decreasing sensitivity to NK cells via upregulation of MHC I class molecules [43]. The gene discussed is CD274; the disease is neoplasm.