Treatment of a panel of selected DepMap cancer lines from diverse tissue origin with HS-276 showed high concordance of MAP3K7 gene score with response to TAK1 kinase inhibition (Fig. 7F) and blockage of TNFα with Etanercept or inhibition of RIPK1 with Nec-1s could rescue the growth defect caused by TAK1 inhibition in eight tested sensitive cancer lines (Fig. 7G) indicating a conserved mechanism of dependency on TAK1 function in many cancer types. The gene discussed is MAP3K7; the disease is cancer.