Proteins like S100A14 have been shown to inhibit metastasis by curtailing store-operated Ca2+ entry (.Zhu et al. 2017), while ORAI2 expression has been linked to GC prognosis and tumorigenicity through Ca2+ signaling modulation (.Kokoska, Smith, Wolff, Deshpande, Rieckenberg, Banan and Miller 1998, Wu et al. 2021). This evidence concerns the gene ORAI2 and gastric cancer.