COL12A1 and neoplasm: In particular, COL12A1, a critical regulator of tumor matrix organization, was more abundant in tamoxifen-resistant patients in both the EMC and NKI-AVL + RUMC cohorts, with average log2 fold changes of 0.86 (FDR = 1.36 × 10−22) and 0.74 (FDR = 2.07 × 10−7), respectively (Fig. 5c).