CD86 and melanoma: For example, Xcl1 and Ccl5 mediate cDC1 infiltration into tumors,47 whereas Cxcl9 and Cxcl10 are important for DC-T cell interaction by recruitment of CXCR3+ effector T cells48 49 and for effective T cell-mediated melanoma growth control.25 Moreover, the genes for DC-derived cytokine Il12 for induction of Th1 response and costimulatory molecules for T cell stimulation Cd40 and Cd86 were strongly upregulated during BRAFi-sensitive phase and downregulated in resistant tumors (figure 4G).