Using a transgenic melanoma mouse model, our group previously demonstrated that migratory skin cDC2 cross-present tumor antigens to CD8+ T cells.30 Another report confirmed that cDC2 are essential for CD4+ T cell responses in tumor models.29 Interestingly, D4M tumors contained cDC2 expressing the FcγRI/CD64 as confirmed by the Zbtb46GFP/WT reporter mouse model that allowed to distinguish CD64+ cDC2 from monocyte-derived cells46 and macrophages.50 Similar DC subtypes have been described in infection, for example, with Listeria or respiratory virus infection. Here, CD4 is linked to melanoma.