Although LC do not infiltrate the D4M tumor model, it is well established that LC can present antigens derived from the skin to CD4+ and CD8+ T cells in the draining LN.59 LC are localized in the epidermis next to melanoma, therefore playing an important role in antitumor immunity.60 In fact, we previously demonstrated that LC can cross-present gp100 tumor-associated antigen in tumor-draining LN, although to a lesser extent compared with cDC1 and cDC2.30 Here, CD4 is linked to melanoma.