The variant rs992157, located in the intron of PNKD and TMBIM1, was found to be significantly associated with the susceptibility and progression of CRC in both European and Chinese populations, possibly via the up-regulation of TMBIM1. 41,42 Similarly, disrupted PNKD function may reduce glutathione levels, increasing oxidative stress and inflammation.43 Here, TMBIM1 is linked to colorectal carcinoma.