It has been proposed to promote the growth and invasion of colon cancer cells, probably via the PI3K/AKT pathway,38 and has been reported to be associated with poor prognosis in advanced colon cancer, suggesting the potential utility of CXC family chemokines as prognostic or predictive biomarkers and possible drug targets in CRC.39 The gene discussed is AKT1; the disease is colorectal carcinoma.