Moreover, using CD40- and FcγR-humanized C57BL/6J mice harbouring MB49 or UPPL1541 tumours, it was shown that the human anti-CD40 agonist antibody 2141-V11 caused reduced tumour size and that this effect was enhanced by cotreatment with IL-15 [37▪]. This evidence concerns the gene IL15 and neoplasm.