KLHL6 and diffuse large B-cell lymphoma: Introduction of wild-type (WT) and different KLHL6 mutants to GCB and ABC DLBCL cell lines with endogenous KLHL6 expression recapitulated the findings from DLBCL samples and confirmed that BTB domain mutants were localized in nonphysiologic cytosolic patterns (Fig. 2I and J; Supplementary Fig. S2D).