Analysis of total and surface protein levels of CD79A, CD79B, and IgM/IgG in isogenic DLBCL cell lines with endogenous KLHL6 (parental), or overexpression of KLHL6WT or recurrent mutants revealed differential impacts by the BTB and Kelch mutations on the BCR phenotype. This evidence concerns the gene KLHL6 and diffuse large B-cell lymphoma.