In multivariable analysis, factors associated with rupture were preoperative albumin level (OR 1.23, 95% c.i. 1.11 to 1.32; P = 0.001), Model for End-Stage Liver Disease (MELD) score (OR 1.08, 1.04 to 1.12; P = 0.003), ASA grade (OR 3.53, 1.64 to 7.61; P = 0.002), and Child–Pugh grade (OR 43.12, 1.52 to 1200.54; P = 0.027). This evidence concerns the gene ALB and End Stage Liver Disease.