Additionally, STAT3 has been reported as promoting a youthful epigenetic state in articular chondrocytes [47], and interacting with STAT1 and thereby regulating senescence and inflammation, which might indicate its potential as a therapeutic target for treating the senescence-associated inflammatory phenotype in obesity-related type 2 diabetes [48]. Here, STAT3 is linked to obesity due to melanocortin 4 receptor deficiency.