PDLIM7 and myeloid sarcoma: Further investigation will be required to disseminate the serological role for other proteins, notably EBNA-2 and LMP-1, along with relations to viral load, which has overlapping associations but limited correlation to serological response.26,27 Although EBV is the most prominent viral risk factor, other infectious agents, particularly other herpes viruses, such as cytomegalovirus and human herpes virus 6, are known to modify MS risk and disease activity.4 Further studies should examine the causal inference of these viruses and their potential interaction with EBV and HLA in MS pathogenesis.