Recent studies have shown that IGFBP5 activates inflammation signaling directly by influencing endothelial glycolysis in diabetic mice.47 Furthermore, hyperglycemia induces the IGFBP5-mediated cellular processes in glomerular endothelial, mesangial, and myocardial cells.47, –49 We have shown that Set7 plays an important role for IGFBP5 human gene regulation mediated by H3K4me1/2 on the enhancer region in glomerular endothelial cells. The gene discussed is IGFBP5; the disease is Hyperglycemia.