To assess diabetes-associated pathways regulated by Set7, we performed gene set enrichment analysis (GSEA) on the scRNA-seq clusters and identified four major reactome pathways involving respiratory electron transport (abbreviated as OXPHOS), ribosomal RNA (rRNA) processing, extracellular matrix organization (EMO), and peroxisome proliferator-activated receptor alpha (PPARα) activation (Figure 2C). The gene discussed is PPARA; the disease is diabetes mellitus.