The Set7−/− mice were crossed with apolipoprotein E–deficient (ApoE−/−) mice to accelerate DKD and vascular complication.27 We confirmed that Set7 and ApoE were absent at the mRNA level in the kidney cortex isolated from Set7−/−ApoE−/− (referred to as Set7KO) mice (Supplemental Figure 1). Here, APOE is linked to diabetic kidney disease.