IGFBP5 and diabetic kidney disease: The regulatory dosage of renal Igfbp5 is critical because the transcription factor is a marker of endothelial identity30,31 and is closely associated with the development of DKD.32,33 While Igfbp5 expression was elevated in diabetic Set7WT mice, mRNA levels remain unchanged in the kidney cortex in Set7KO mice (Supplemental Figure 3A).