Recently, heterozygous variants in COL1A2 gene, which usually cause osteogenesis imperfecta type II, III and IV as well as several types of Ehler-Danlos syndrome, were reported in three families with non-syndromic dentinogenesis imperfecta by Lee and co-authors [23]. The gene discussed is COL1A2; the disease is osteogenesis imperfecta type 2.