Pro-inflammatory cytokines, such as IL-12 [207], promote the maturation of monocyte-derived DCs (mMO-DCs) to eventually deliver the tumor antigens to CD8+ T cells in tumor-draining lymph nodes, which prime the formation of tumor-specific cytolytic T cells (CTLs) and the subsequent antitumor adaptive immune responses [208–210]. The gene discussed is CD8A; the disease is neoplasm.