NLRP3 and Alzheimer disease: According to research, concomitantly activation of NLRP3 inflammasome, numerous pro-inflammatory cytokines generated, like IL-6 and TNF-α, ae well as GFAP (Ren et al. 2019; Babić Leko et al. 2020), more specific in the nervous system (Hol and Pekny 2015), leading to an increased rate of neuronal death and the degradation of AD.