And here, by crossing CreER with FoxG1fl/fl lines combined with tamoxifen (TM) induction, and further injecting Aβ25–35 drug into the lateral ventricle, FoxG1 was conditionally overexpressed in mature neurons in Aβ25–35-induced AD vivo model and to continue exploring the effects of FoxG1 in improving pathology of AD. This evidence concerns the gene FOXG1 and Alzheimer disease.