SERPINE1 and human prion disease: Similarly, the levels of miR-146a in the brain have been shown to assist in the diagnosis, prognosis, or treatment of transmissible spongiform encephalopathies (TSEs) (Pogue et al. 2022), while miR-30b can modulate the disease course and immune response in hypoxic-ischemic encephalopathy (HIE) through the regulation of PAI-1 (Wang and Jia 2021).