The results were remarkably similar to those obtained in parental A549 cells: only WT PR8 infection resulted in strong nuclear PABPC1 accumulation (Fig. 2B and C), nuclear poly(A) accumulation did not correlate with nuclear PABPC1 and was observed in cells infected by the WT and both mutant viruses (Fig. 2D), and the depletion of ACTB, G6PD, and POLR2A was significantly attenuated by both the PA-X and NS1 mutations (Fig. 2E through G). Here, PABPC1 is linked to infection.