For example, the activation of JNK and Yorkie (a YAP homolog and Hippo pathway effector) in Drosophila imaginal epithelia induces the generation of PACCs by downregulating cyclin B.[51] The knockdown of cyclin B1 also significantly increased the frequency of PACCs in breast and ovarian cancers.[52] As the translocation of cyclin B1‐CDK1 to the nucleus is necessary for mitosis entry, the cytoplasmic localization of cyclin B1 may delay the G2/M transition and contribute to PACC formation. This evidence concerns the gene CCNB1 and ovarian carcinoma.