The dysregulation of cyclin‐CDK activity is also associated with PACC formation (Figure 2d).[42] Amplification of CCNE1 (encoding G1/S specific cyclin E1) facilitates polyploidization, independent of the cancer type.[6] A previous study showed that cyclin E1 overexpression promotes liver‐specific polyploidization in hepatocellular adenomas through premature S‐phase entry and erroneous DNA replication.[43] Zeng J. et al. Here, CCNE1 is linked to cancer.