MRGPRX2 can regulate mast cell degranulation by influencing intracellular Ca2+ concentration via phosphatidylinositol 3 kinase (PI3K)/serum‐threonine kinase (AKT) and phospholipase C gamma (PLCγ) signaling43 and MRGPRX2‐SOCE‐STIM1 pathway in mast cells would resolve the treatment of pseudo‐allergic reactions in humans.44 The gene discussed is STIM1; the disease is allergic disease.