STAT3 and neoplasm: Apart from dendrimers, Gregory et al. synthesizeda synthetic proteinnanoparticle (SPNP) consisting of polymerized human serum albumin(HSA), coloaded with the tumor cell-penetrating peptide iRGD and siRNAagainst a transcriptional activator (STAT3) associated with GBM progression.29 While the accumulation of iRGD-loaded SPNPswas 40% higher in the brains of tumor-bearing mice than in nontumor-bearingmice, the distribution of SPNPs within the brain was minimal comparedto that in other organs.