While in non‐recurrent samples, C1 no longer participated in VEGF and MIF signal transduction with C2, C3, and C6, while C6 sent signals to C2 and C3 via MIF pathway, and C2 sent out signals through Interleukin 1 (IL1) pathway, which could be related to anti‐tumoral immunity and pleural effusion control (Figure 5A‐iii,iv). Here, VEGFA is linked to Pleural effusion.