In gastric cancer, CLDN4 was found to enhance the proliferation, invasion and EMT of gastric cancer cells, and was reversed by miR‐596 and miR‐3620‐3p,56 while the overexpression of CLDN4 induced EMT of ovarian cancer cells through PI3K/Akt and the EMT transcription factor Twist1 signal pathway similarly.57 The gene discussed is TWIST1; the disease is ovarian carcinoma.