For instance, tumors harboring these mutations often exhibit a lack of PD-L1 expression upon IFN-γ exposure, making them less susceptible to T-cell-mediated destruction.61 IFN-γ plays a pivotal role in tumor immunity by enhancing antigen presentation, facilitating immune cell recruitment, and exerting anti-proliferative effects on tumors. The gene discussed is CD274; the disease is neoplasm.