Moreover, elevated IL-8 expression leads to the recruitment of myeloid cell lines including MDSCs, CD15+ monocytes, and neutrophils, which have been shown to suppress adaptive T-cell antitumor immunity,56–58 Transcriptomic analysis of circulating and tumor-infiltrating IL-8-producing MDSCs has revealed an increased expression of pro-inflammatory myeloid genes coupled with downregulation of antigen-presentation and interferon-inducible genes, further underscoring the role of IL-8 in compromising adaptive immunity in the context of the GU tumors.59 This evidence concerns the gene CXCL8 and neoplasm.