Epigenetic modulators can enhance the anti-tumor response of ICIs by increasing the production of chemokines crucial for attracting CD8+ T-cells to the tumor microenvironment.89 Despite these findings, the exact role of the tumor’s epigenetic makeup in resistance, particularly in relation to T-cell exhaustion, remains unclear, necessitating more research in this area.90 Mutations and epigenetic silencing within the interferon receptor signaling pathway have been shown to negate the anti-tumor effects of IFN-γ, demonstrating how the tumor can escape immune surveillance. This evidence concerns the gene IFNAR2 and neoplasm.