Therefore, the present study was designed to investigate the effects of SFN and EA on the improvement of skeletal muscles function and molecular mechanisms in mice with sarcopenia by observing the morphological changes, oxidative stress levels, expression of AMPK/SIRT1/PGC-1ɑ pathway and downstream proteins in the skeletal muscles of SAMP8 mice. This evidence concerns the gene PPARGC1A and sarcopenia.